Remote Fulfillment by FBA vs. In Country Fulfillment vs. PAN5

Hi all. We are unsure of which option out of these three would be the best option for us. Sending stock to EU FBA is a nightmare and super time consuming, so the Remove Fulfillment by FBA sounds like a good solution. But what are the downsides? Longer shipping time? if so how much longer? And does it cost much much more in terms of FBA fees when compared to in-country fulfillment? Can EU customers still get our products on Prime when using Remote Fulfillment? I would really appreciate your views and opinions on these. Thanks!